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Date/Time:  10/10/19 7:22 GMT
 

3-Bromocinnamic acid

Name:3-Bromocinnamic acid
Synonyms:RARECHEM BK HC T307; TRANS-3-BROMOCINNAMIC ACID; M-BROMOCINNAMIC ACID;
M-BROMOPHENYLACRYLIC ACID; BROMOCINNAMIC ACID,3-;3-BROMOCINNAMIC ACID; AKOS BBS-
00006566; AKOS B004044
CAS NO.:32862-97-8
Formula:C9H7BrO2
Molecula , r weight: 227.05
EINECS NO.:251-267-7
Melting point: 177-179 °C
Appearance: Colorless crystal
Vapor pressure: 0.0±0.8 mmHg at 25°C
Refractive index: 1.648
Storage: Shading, confined preservation, dry, ensure good ventilation or exhaust
in the workshop
Stability: Stable under normal temperature and pressure
Keywords: 3-Bromocinnamic acid, spices, essence, Synthetic essence,

General description
3-Bromocinnamic acid is the metabolite of cinromide (3-Bromo-N-ethylcinnamamide)
and can be analysed in plasma by high-performance liquid chromatographic method.
Simultaneous determination of the anticonvulsants, cinromide (3-bromo-n-
ethylcinnamamide), 3-bromocinnamamide, and carbamazepine in plasma by high-
performance liquid chromatography.
3-Bromocinnamic acid is used as an organic synthesis of raw materials, fine
chemicals, pharmaceutical intermediates.

Abstract
A high-performance liquid chromatographic method is described for monitoring
plasma concentrations of cinromide (3-bromo-N-ethylcinnamamide) and its de-
ethylated metabolite. Carbamazepine levels can be easily measured by the same
technique. The N-isopropyl analogue of cinromide is used as internal standard, and
all compounds are easily separated on a reversed-phase column operated at 55
degrees with a small-diameter pre-column maintained at the same temperature. The
extraction is rapid and generally applicable to plasma and urine samples that are
to be analyzed by reversed-phase chromatography. Short- and long-term
reproducibility studies show less than 4% relative standard deviation for
replicate determinations for all drugs. Limits of quantitation are 10-20 ng/ml
with an internal standard concentration of 3 micrograms/ml. Another metabolite of
cinromide, 3-bromocinnamic acid, which may have some anticonvulsant effect, can be
analyzed simultaneously by buffering the mobile phase and adding an ion-pairing
reagent. Storage: Pay attention to the source of fire, especially to avoid
sunlight, and store in a cool place.
3-Bromocinnamic acid
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