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Contact: hanbon
Company: Jiangsu Hanbon Science&Technology Co., LTD
No.1-9 jixian road, economic development zone
huaian 223005
China
Phone: 86-0517-83706900
E-Mail: Send Inquiry 1st year
Date/Time:  1/4/24 1:33 GMT
 

Biopharm Purification Equipment


Biopharm purification equipment independently developed by Hanbon includes
Chromatography columns, Chromatography system, In-line buffer dilution system,
Filtration system, Single-use system, etc. The device software meets the
requirements of GLP/GMP regulations and FDA 21CFR part 11 requirements and has
a complete IQ/OQ/PQ verification file system that can provide document support
for user GMP/FDA certification.

Basic Characteristics Of Chromatography Resins
Resin matrix: the finer and more uniform the particle size, the higher the
resolution, but also the higher the backpressure (with the exception of the
Source matrix);

Physical stability: new generation resins are more robust and can withstand
high flow rates while maintaining a stable column bed volume and structure,
eliminating the need for frequent column loading operations and improving
reproducibility;

hemical stability: the new generation of resins can withstand extreme pH, high
salinity, pro-solvents and organic solvents, facilitating the development of
separation conditions and in-situ cleaning (CIP), greatly extending resin life
and improving reproducibility.

Different packing materials can be used for different sample separations,
requiring different columns and systems to be used with them.

Application Of Chromatography And Filtration Techniques In Vaccine Purification

Antibody drugs (mono-, di-, poly-, and ADCs) are novel therapeutics with high
efficiency, low toxicity, and low side effects, and are widely used in cancer,
autoimmune diseases, infectious diseases, and other fields. Antibody-drug
purification protocols need to be optimized and adjusted according to specific
antibody types and requirements, and downstream links usually include the
following steps:

Cell harvesting and fragmentation

Affinity chromatography

Ion exchange chromatography

Size exclusion chromatography

Regeneration and concentration

Hanbon's chromatography systems, filtration systems, in-line dosing systems,
and other products are inextricably linked to the separation and purification
of antibody drugs and are essential tools for the preparation of high-quality
antibody drugs, both in the process development and production stages.

Application Of Chromatography And Filtration Techniques In Antibody
Purification

Vaccines are an effective means of preventing infectious diseases. In the
process of vaccine preparation, viruses or bacteria need to be produced first
by cell culture, etc., and then inactivated and lysed to obtain the vaccine
stock solution. Next, the vaccine stock solution needs to be isolated and
purified to obtain a high-purity vaccine product. In this biopharma
purification process, Hanbon's chromatography system and ultrafiltration system
can be used to separate and purify the target proteins in the vaccine stock
solution to obtain a high-purity vaccine product. Specifically, affinity
chromatography, ion exchange chromatography, and gel chromatography can be used
to remove impurities from the vaccine raw material solution to obtain high
purity vaccine products.

For more information about biopharma downstream processing, please feel free to
contact us!

Minimum Order: 1 sets

Biopharm Purification Equipment
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