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Date/Time:  10/10/19 7:36 GMT
 

Hydrogenated cinnamic acid

Name: Hydrogenated cinnamic acid (3-phenyl propionic acid)
Chinese name: Qing Hua Rou Gui Suan
Other names :
ARECHEM AL BO 0168;
Benzenepropionic acid;
benzenepropionicacid,hydrocinnamic;
Ph , enylpropanoid acid
; propanoicacid;
3-phenyl-;
4-propionicacid,3-phenyl-;
5- 3-PHENYLPROPANOIC ACID.
CAS No.: 501-52-0
Molecular formula: C9H10O2

Molecular weight: 150.17
EINECS number: 207-924-5
Purity: ≥98%
Packing specification: 25 kg / packaging

Use limit: FEMA (mg / kg): beverage 0.02 ~ 1.0; cold drink 0.48 ~ 1.0; candy 0.80
~ 4.0; baked goods 17.0; gel, pudding, 1.2; dairy products 2.0;FDA, §172.515
(2000): The amount is limited.The perfume ingredients used to formulate the
fragrance must not exceed the maximum allowable amount and maximum allowable
residue in GB 2760.
Chemical properties: white prismatic crystals. The temperature of 48.5° C, the
boiling point of 280°C, 125-129°C (0.8 kPa), the relative density of 1.071.
Soluble in hot water, alcohol, benzene, chloroform, ether, glacial acetic acid,
petroleum ether and carbon disulfide, slightly soluble in cold water. It can
volatilize with water vapor.
Usage: This product is a flavoring agent for spices. Used as a pharmaceutical
intermediate, also used in organic synthesis.The it can be used as intermediate of
rasagiline
Storage: Pay attention to the source of fire, especially to avoid sunlight, and
store in a cool place.

Keywords: Hydrogenated cinnamic acid (3-phenylpropionic acid), flavors, spices,
synthetic flavors, intermediate drug, rasagiline

Description:
Hydrogenated cinnamic acid (3-phenylpropionic acid) is a white prismatic crystal
having a melting point of 48.5 °C, a boiling point of 280°C, 125-129°C (0.8
kPa), and a relative density of 1.071. Soluble in hot water, alcohol, benzene,
chloroform, ether, glacial acetic acid, petroleum ether and carbon disulfide,
slightly soluble in cold water. It can volatilize with water vapor.
Parkinson's disease, also known as "tremor palsy", is a central nervous system
degenerative disease, most commonly found in middle-aged and elderly people, and
is listed by the World Health Organization as one of the "world's difficult
diseases." With the aging of the society, there are more than 1.8 million
Parkinson's patients in China, and the incidence is increasing at a rate of 0.1%
per year. Because there is no suitable medical treatment, about 20-25% of patients
eventually lose their lives. ability. In order to solve this problem, in 2005,
Denmark LUNDBECK company and Israel TEVA company developed a rasagiline through
long-term joint experiments. Compared with the first generation of therapeutic
drugs, according to the Canadian Medical Post report, rasagiline treatment can
relieve the symptoms of Parkinson's disease for up to 6 years, and also has a
certain protective effect on the nerves. However, due to the high price of raw
materials and the complicated preparation methods, the price of rasagiline has
remained high and the patients are suffering. The latest research found that
rasagiline is prepared by using low-cost hydrogen cinnamic acid as an
intermediate. It has the advantages of simple operation, low cost and high yield.
The price of regagiran is cheaper than other drugs. More than 50% brings new hope
to patients.
In addition, the recent International Institute of Chemistry has shown that
hydrogenated cinnamic acid can also be used as an intermediate in the treatment of
the diabetes drug glibenclamide. Diabetes is a worldwide stubborn disease, and its
alias for foreign countries is called "silent killer." There are currently more
than 92 million diabetic patients in China, and another 100 million are potential
patients. Glibenclamide is the most effective drug for oral hypoglycemic, but it
has been expensive due to the price of raw materials and has strong toxic side
effects. In the modern pharmaceutical industry, the cinnamon series-hydrocinnamic
acid is used as an intermediate, which has certain auxiliary effects on reducing
side effects and lowering blood sugar.
Hydrogenated cinnamic acid
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