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Contact: Tom Bryant
Company: HUBEI YUANCHENG SAICHUANG TECHNOLOGY CO.,LTD
496 ZHONGSHAN ROAD, WUCHANG DISTRICT, WUHAN, HUBEI,CHINA
Wuhan 430064
China
Phone: +86-27-50756049
Fax: +86-27-68886696
E-Mail: Send Inquiry
Date/Time:  12/7/15 9:03 GMT
 

Obeticholic Acid CAS: 459789-99-2 (My E-mail: tom@chembj.com)

Obeticholic Acid CAS: 459789-99-2

Product Name: Obeticholic Acid
CAS: 459789-99-2
MF: C26H44O4
MW: 420.63
density 1.091
Appearance : White powders
Purity : 99%
Package : 1kg/foil bag
Related categories : pharmaceutical intermediates; pharmaceutical raw
materials; Aobei acid; API
Usage : Obeticholic Acid is a potent and selective farnesoid X receptor (FXR)
agonist with EC50 of 99 nM.

In vitro:
In HuH7 cells, Obeticholic Acid acts as a potent FXR agonist with EC50 of 85
nM.

In vivo:
In rat cholestasis model, Obeticholic Acid promotes bile flow, and protects
hepatocytes against acute necrosis caused by LCA. Obeticholic Acid (p.o.)
improves proteinuria, ameliorates renal structural changes, and modulates renal
inflammation and oxidative stress in WD-fed DBA mice. In thioacetamide (TAA)-
intoxicated and bile-duct-ligated (BDL) rats, Obeticholic Acid (30 mg/kg p.o.)
reactivates the FXR downstream signaling pathway and decreases portal pressure
by lowering total IHVR without deleterious systemic hypotension.

Related FXR Products :
Vincristine CAS: 57-22-7
Sunitinib Malate CAS: 341031-54-7
Saracatinib (AZD0530) CAS: 379231-04-6
(+)-JQ1 CAS: 1268524-70-4
Osimertinib (AZD9291) CAS: 1421373-66-1
Nintedanib (BIBF 1120) CAS: 656247-17-5
BIBF-1120 CAS: 928326-83-4

For Your Reference

Place of origin : China
Certificate : ISO9001:2008, KOSHER, GMP, SGS
Quality Standard : USP
Minimum Order Quantity : 10 g
Production Capacity : 1000 Kg/Month

Package & Delivery

Package : Foil bag, Foil tin , Drum or as your request
Payment Method : T/T, Western Union, MoneyGram, Bitcoin
Port of Loading : Shanghai, Shenzhen, Hongkong
Shipping Method : EMS, DHL, FeDex, UPS (Note: Best Choice For you will be
adopted)
Leading time : Within 1 day upon confirming payment
Delivery time : Within 6 working days after confirming payment (Note: door to
door service)

Why Choose Us ?

1. Professionalism: We specialized in exporting pharmaceutical intermediate for
15 years, you must want to find a professional manufacturer like us with much
experience.
2. Quality : We are a professional leading factory for pharmaceutical
intermediate in China, We had stable customers and exported to Germany, Spain,
UK, USA, Australia, Middle East, and any other countries.
3. Package : Experienced package with special arrangement, high rate of customs
clearance can be guaranteed.
4. Delivery: We have products in stock, so we will deliver them within 24 hours
after payment. Tracking number will be given in no time.
5. Service : Best Service with after-sale service and consultation

Minimum Order: 10 grams

Obeticholic Acid  CAS: 459789-99-2    (My E-mail: tom@chembj.com)
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