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Alias: Tetracaine hydrochloride,TetracaineHCL;pontocaine
CAS NO.: 136-47-0
Melting point: 149°C
Grade: Pharmaceutical Grade
Storage: Closed, confined and shading preservation
Usage: Local anesthetic; Mainly used in mucosa anesthetic. The function is
stronger than Procaine and Lidocaine.
Catergory: API intermediates;local anesthetic;Sodium
channel;Amines;Aromatics;Intermediates & Fine
Chemicals;Pharmaceuticals;Pharmaceutical intermediate;pharmaceutical raw
Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is
formed through an acid-catalyzed esterification reaction. Base-catalyzed
transesterification is achieved by boiling the ethyl ester of 4-
butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a
small amount of sodium ethoxide.
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and
Dicaine) is a potent local anesthetic of the ester group. It is mainly used
topically in ophthalmology and as an antipruritic, and it has been used in
In biomedical research, tetracaine is used to alter the function of calcium
release channels (ryanodine receptors) that control the release of calcium from
intracellular stores. Tetracaine is an allosteric blocker of channel function.
At low concentrations, tetracaine causes an initial inhibition of spontaneous
calcium release events, while at high concentrations, tetracaine blocks release
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