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Company: BOC Sciences
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New York 11967
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Date/Time:  6/13/19 3:32 GMT

Trastuzumab emtansine

Trastuzumab emtansine is an antibody-drug conjugate (ADC) consisting of the
recombinant anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody
trastuzumab conjugated to the maytansinoid DM1 via a nonreducible thioether
linkage (MCC) with potential antineoplastic activity. The trastuzumab moiety of
this ADC binds to HER2 on tumor cell surface surfaces. Upon internalization, the
DM1 moiety is released and binds to tubulin, thereby disrupting microtubule
assembly/disassembly dynamics and inhibiting cell division and the proliferation
of cancer cells that overexpress HER2. Linkage of antibody and drug through a
nonreducible linker has been reported to contribute to the improved efficacy and
reduced toxicity of this ADC compared to similar ADCs constructed with reducible
linkers. , ansine-cas-1018448-65-1-item-

Minimum Order: 1 grams

Trastuzumab emtansine
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SOURCE: Import-Export Bulletin Board (
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