Agomelatine CAS No. ：138112-76-2 99.0% purity min. Health product raw mater

Product name:Agomelatine
Other name:N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide; N-[2-(7-methoxynaphthalen-1-
yl)ethyl]acetamide ,
CAS No.:138112-76-2
Molecular formula:C15H17NO2
Molecular weight:243.3082
Purity:99.0%
Appearance:Whit , e powder
Packing:1kg/bag 25kg /drum
Application:Health product raw material
3.Product introduction
Agomelatine is a new type of antidepressant. Its mechanism of action breaks
through the traditional monoamine transmitter system. It activates melatonin
receptors, MT1 and MT2, and antagonizes 5-HT2C receptors. It can improve sleep
quality and restore biological rhythm while having antidepressant effect; among
them, by antagonizing the 5-HT2C receptor of the postsynaptic membrane, it can
increase the release of DA and NE in the prefrontal cortex and play an
antidepressant role. When MT agonism and 5-HT2C receptor antagonism exist at the
same time, a unique synergistic effect can be produced to promote the release of
more DA and NE in the PFC brain area, further strengthening the antidepressant
effect. In addition, agomelatine can also promote the release of brain-derived
neurotrophic factor in the PFC and block the stress-induced release of glutamate in
the amygdala brain region.
4.Feature
(1) Dual regulation: It can not only regulate the release of melatonin, but also
regulate the release of 5-hydroxytryptamine and norepinephrine, thus playing a role
in regulating mood, sleep, pain and so on.
(2) Improvement of sleep: Agomelatine is that may improve insomnia without causing
drowsiness or coma.
(3) Improve cognitive function: Agomelatine can improve cognitive function by
improving neuroplasticity in the hippocampus.
(4) High safety: Compared with other antidepressants, the drug has relatively less
side effects when treating depression, and will not affect sexual function and body
weight.
5.Applications
Agomelatine is for antidepressant that is also a melatonin antagonist. It reduces
depressive symptoms by modulating levels of melatonin MT1 receptors (to reduce
cortical alarm signals) and MT2 receptors (to circadian rhythms of sleep) and
serotonin. Taken at night to mimic the natural rhythm of melatonin release, it can
significantly improve sleep quality.

Minimum Order: 1 bags

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