Buffer Dilution/ Conditioning System

Bio-Con® auto dilution system is to mix various concentrated buffer solutions,
including acid, alkali, salt, etc., with injection water online to prepare the
required buffer solution. Different concentrations can be accurately prepared
according to specific usage situations. The online dilution and preparation
system can quickly achieve stable control parameters. It can also be integrated
with the Bio-Pro® pilot & process chromatography system or Bio-TFF tangential
flow filtration system as a whole, continuously completing the process of
"preparation + chromatography or preparation + tangential flow filtration",
overall control and data recording. The overall system is based on DCS+BATCH
system control, which can achieve centralized management, centralized control,
batch processing, and batch control of the system, with a higher degree of
automation.

The Difference Between Dilution And In-Line Dilution

The Inline Dilution System is similar to the two-pump gradient mode and allows
for buffer dilution within a certain range. However, given the solubility of
the mother liquor, pH shift after dilution and other phenomena, the robustness
of buffer formulation is limited in large-scale applications.

The in-line conditioning system uses a single component mother liquor of acid
system, base system, salt system, water and additive system to perform buffer
formulation, simulating the traditional laboratory formulation mode, with
corresponding pH and conductivity feedback adjustment added during the
formulation process for improving buffer preparation stability.



The in-line buffer configuration is a single-component buffer concentrate with
high solubility and can therefore be diluted up to a hundred times, which
allows the volume of the buffer tank to be reduced a hundred times and can
really solve the efficiency of room utilisation in the dispensing room or
between uses.

It is possible to obtain an in-line buffer configuration system that has
obvious advantages over in-line dilution systems in terms of scalability and
adaptability, and at the same time provides a better solution for modern buffer
preparation.

The Need For In-Line Automatic Buffer Conditioning Systems

Buffer preparation for chromatography and filtration steps in bioprocessing is
a challenge in terms of providing timely buffer delivery, reproducibility, and
good process economics.

Traditionally, buffer preparation relies mostly on manual work, which is
labour-intensive and makes it difficult to avoid human errors, such as
inaccurate weighing or deviations in the dosing of injection water for
dilution. In addition, the target buffer must pass various quality control
tests before it can be used in production, resulting in long dispensing cycles.
The tanks must also be thoroughly cleaned and validated if they are used for
other liquids. Another issue that should not be overlooked is that these large
dispensing and storage tanks take up a lot of money and plant space.

We provide dilution system cleaning, dilution equipment, automated dilution
machine, dilution control, dilution dispenser, etc. For more information about
preparation of pharmaceutical buffer solution, please feel free to contact us!

Minimum Order: 1 sets

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