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Date/Time:  2/11/21 1:55 GMT

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Sibutramine, formerly sold under the brand name Meridia among others, is an
appetite suppressant which has been discontinued in many countries. Until 2010,
it was widely marketed and prescribed as an adjunct in the treatment of obesity
along with diet and exercise. It has been associated with increased
cardiovascular events and strokes and has been withdrawn from the market in
several countries and regions including Australia, Canada, China, the European
Union, Hong Kong, India, Mexico, New Zealand, the Philippines, Thailand, the
United Kingdom, and the United States. However, the drug remains available in
some countries. Buy sibutramine online.

What should I discuss with my healthcare provider before taking sibutramine?
Do not use sibutramine if you have taken an MAO inhibitor such as furazolidone
(Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect),
selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the last 14 days.
Serious, life threatening side effects can occur if you use sibutramine before
the MAO inhibitor has cleared from your body.

You should not take this medication if you are allergic to sibutramine, or if
you have:

severe or uncontrolled hypertension (high blood pressure);
an eating disorder (anorexia or bulimia);
a history of coronary artery disease (atherosclerosis);
a history of heart disease (congestive heart failure, heart rhythm disorder);
a history of heart attack or stroke; or
if you are taking stimulant diet pills.
If you have any of these other conditions, you may need a sibutramine dose
adjustment or special tests:

high blood pressure;
liver disease;
kidney disease;
underactive thyroid;
epilepsy or seizure disorder;
a bleeding or blood clotting disorder;
a history of gallstones; or
if you are older than 65 or younger than 16.
How should I take sibutramine?
Take exactly as prescribed by your doctor. Do not take in larger or smaller
amounts or for longer than recommended. Follow the directions on your
prescription label.

Sibutramine is usually taken once daily. Follow your doctor’s instructions.

Your doctor may occasionally change your dose to make sure you get the best

Sibutramine can be taken with or without food.

You should lose at least 4 pounds during the first 4 weeks of taking
sibutramine and eating a low calorie diet. Tell your doctor if you do not lose
at least 4 pounds after taking the medication for 4 weeks.

Your blood pressure and pulse will need to be checked often. Visit your doctor

Sibutramine should not be taken for longer than 2 years.

Store at room temperature away from moisture, heat, and light.

Do not share sibutramine with another person. Keep the medication in a place
where others cannot get to it.

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Sibutramine is indicated for the management of obesity, including weight loss
and maintenance of weight loss, and should be used in conjunction with a
reduced calorie diet. Sibutramine is recommended for obese patients with an
initial body mass index ≥ 30 kg/m2, or ≥ 27 kg/m2 in the presence of other risk
factors (e.g., diabetes, dyslipidemia, controlled hypertension).

Sibutramine assists with weight-loss by altering neurotransmitters within the
brain. Neurotransmitters are chemicals that are produced and released by nerves
in order to communicate with other nerves. Released neurotransmitters may
attach to other nerves or they may be taken up again by the nerves that release
them, a process termed reuptake. Sibutramine blocks the reuptake of the
neurotransmitters dopamine, norepinephrine, and serotonin. Blocking the
reuptake of neurotransmitters alters the balance of neurotransmitters within
the nerve cells and thereby affect nerve function and interaction.

Patients taking sibutramine may achieve a 5-10% reduction from their baseline
weight. Additionally, sibutramine-assisted weight loss has been accompanied by
improvement in blood lipids (e.g, cholesterol). Sibutramine was approved by the
FDA in 1997.

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CAS ID: 106650-56-0
Molar mass: 279.85 g/mol
Formula: C17H26ClN
Other names: BTS-54524
Trade name: Meridia, others
Elimination half-life: 1 hour (sibutramine), 14 hours (M1) & 16 hours (M2)



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