C17H22BrNO3 API Raw Material 1953-04-4 Galantamine Hydrobromide

Detail Information:
Galantamine Hydrobromide
Galantamine Hydrobromide CAS: 1953-04-4
Galantamine Hydrobromide MF: C17H22BrNO3
Galantamine Hydrobromide MW: 368.27
Galantamine Hydrobromide EINECS: 217-780-5
Product Categories: Alkaloids;Alkaloids (Others);Biochemistry;Functional
Products;Heterocycles;Intermediates & Fine
Chemicals;Pharmaceuticals;API's;Acetylchol , ine receptor;API;Chiral
Reagents;Reminyl;Other APIs;Pharmaceutical intermediates
MP 256 °C
Storage temp. −20°C
Chemical Properties White to Off-White Powder
Usage A selective acetylcholinesterase inhibitor. A therapeutic agent for the
treatment and prevention of Alzheimer's disease and other diseases resulting from
reduced neuronal metabolism.
Usage Alzheimer treatment;Cholinesterase inhibitor
Usage anticholinesterase, analgesic, antiAlzheimer



Description:
Galanthamine is natural extracted from Lycoris radiate, is a tertiary alkaloid
derived from snowdrop and closely related species. It acts as a reversible
competitive acetylcholinesterase (AChE) inhibitor, while acts weaker on
butyrylcholinesterase (BuChE). It is used in the treatment of disorders of the
central nervous system and may be used as an antidote to nonpolarizing muscle
relaxants. Galantamine hydrobromide is a white to almost white powder; Sparingly
soluble in water; Insoluble chloroform, ether and alcohol.



Galantamine hydrobromide is the hydrobromide salt of galantamine and is a
cholinesterase inhibitor can be extracted from Amaryllidaceae Lycoris plant. The
III-phase clinical trials in the United Kingdom in 1998 have showed that this drug
had dual mechanism of action of both inhibiting acetylcholinesterase and regulating
nicotinic receptors.

Therefore, galantamine can improve the cognitive abilities of Alzheimer's patients
and has been already applied as the drug of the treatment of mild to severe
Alzheimer's disease (AD) drugs and has entered into market in EC countries.
"Chinese Pharmacopoeia" has included the both the raw material and injection of
galantamine hydrobromide.

Nootropic Raw Ingredient Rivastigmine Tartrate / Galanthamine Hydrobromide Powder 0



Function:



Galanthamine extract is specific, competitive and reversible acetylcholinesterase
inhibitor. It is also an allosteric modulator at nicotinic cholinergic receptor
sites potentiating cholinergic nicotinic neurotransmission. Both the acetylcholine
and nicotine receptors have been suggested as areas related to cognitive
impairment. Initially, Galanthamine extract was used in anesthesiology to
antagonize the effects of non-depolarizing muscle relaxants, and since then it was
rapidly introduced in other areas of medicine, i.e. neurology, ophthalmology,
gastroenterology, intensive care and resuscitation, cardiology, physiotherapy.
Galanthamine extract is a product with broad therapeutic index, allowing "soft"
manifestation of its effect with individual dosing depending on the particular
case.
Several trials already showed that Galantamine 16 and 24 mg/day significantly
benefits the cognitive, functional, and behavioral symptoms of AD as compared with
placebo and proved also to be very effective in symptomatic treatment of senile
dementia of Alzheimer's type.



Galantamine Hydrobromide COA

Items Specification
Appearance Brown to Brown yellow powder(Relate to Purity)
Oder Characteristic
Taste Characteristic
Paiticle size Pass 80 mesh
Loss on drying ≤5%
Heavy metals <10ppm
As <1ppm
Pb <3ppm
Assay Result
Evodiamine ≥10%
Total Plate Count <10000cfu/g or <1000cfu/g(Irradiation)
Yeast & Mold <300cfu/g or 100cfu/g(Irradiation)
E.Coli Negative
Salmonella Negative


Nootropic Raw Ingredient Rivastigmine Tartrate / Galanthamine Hydrobromide Powder 1

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