CMS121 CAS No.:1353224-53-9 98.0% purity min.Neuroprotective, anti-inflam

Product name:CMS121
Other name :CMS-121;
1,2-Benzenediol,4-[4-(cyclopentyloxy) , -2-quinolinyl]-;
4-(4-(cyclopentyloxy)quinolin- , 2-yl)benzene-1,2-diol(CMS121);
ACC,AcetylCoenzy , meACarboxylase,disease,neuroprotective,inhibit,ant , i-
inflammatory,mitochondrial,Alzheimer's,a , ntioxidative,acetylation,Inhibitor,H3K9,Ace
tyl , -CoACarboxylase,CMS121,dementia,ACC1,CMS-121
CA , S No. :1353224-53-9
Molecular formula:C20H19NO3
Molecular weight:321.37
Purity:98.0%
Appearance :Solid
Application:Dietary Supplement Raw Material
3.Product introduction
CMS-121 is a quinolone derivative and orally active acetyl-CoA carboxylase 1 (ACC1)
inhibitor with promising pharmacological properties. Extensive research has been
conducted to investigate the potential benefits of CMS-121 in various areas,
including neuroprotection, anti-inflammatory effects, antioxidative activity, and
its impact on aging-related markers. This compound has shown great potential as a
therapeutic agent for the treatment and prevention of neurological disorders,
cognitive decline, and age-related conditions.
4.Features
(1) Potent activity: CMS-121 exhibits strong pharmacological activity as an acetyl-
CoA carboxylase 1 (ACC1) inhibitor. Its potent inhibitory effect on ACC1 makes it a
promising compound for various therapeutic applications.
(2) Neuroprotective effects: CMS-121 demonstrates significant neuroprotective
properties, safeguarding HT22 cells against ischemic and oxidative damage. This
neuroprotective activity suggests its potential in the treatment of neurological
disorders characterized by such damage.
(3)Anti-inflammatory activity: CMS-121 exhibits notable anti-inflammatory effects,
indicating its ability to modulate the inflammatory response. This property opens
up possibilities for the treatment of inflammatory diseases where regulation of
inflammation is crucial.
(4) Antioxidative activity: CMS-121 displays strong antioxidative activity,
allowing it to counteract oxidative stress-induced damage. This antioxidative
capacity holds potential for addressing diseases associated with oxidative stress.
(5) Renoprotective activity: CMS-121 demonstrates renoprotective effects,
suggesting its potential in the protection and preservation of renal function.
Further research is warranted to elucidate the mechanisms underlying its
renoprotective activity.
(6) Regulation of acetyl-CoA metabolism: CMS-121 regulates acetyl-CoA metabolism,
thereby preserving mitochondrial homeostasis. This regulation may contribute to its
neuroprotective and anti-aging effects, as well as its potential therapeutic
applications in age-related disorders.
(7) Oral bioavailability: CMS-121 can be administered orally, allowing for
convenient and efficient delivery. Its ability to be absorbed and distributed
within the body facilitates its potential as an orally active therapeutic agent.
(8) Potential in aging-related conditions: CMS-121 shows promise in mitigating
cognitive decline, metabolic markers, and transcriptional markers associated with
aging in the brain. These effects position CMS-121 as a potential intervention for
age-related cognitive impairments and molecular changes.
5.Applications
Neuroprotection: In studies conducted on HT22 cells, CMS-121 has demonstrated
significant neuroprotective effects. It effectively protects these cells against
ischemia and oxidative damage, as evidenced by its low EC50 values of 7 nM and 200
nM, respectively. The ability of CMS-121 to safeguard neuronal cells suggests its
potential in combating ischemic conditions and oxidative stress-induced
neurological disorders.
Anti-inflammatory and Antioxidative Effects: CMS-121 exhibits remarkable anti-
inflammatory properties, indicating its ability to modulate the inflammatory
response. By doing so, CMS-121 has the potential to alleviate inflammation in
various tissues and organs, thus holding promise for the treatment of inflammatory
diseases. Additionally, CMS-121 demonstrates potent antioxidative activity,
allowing it to counteract oxidative stress-induced damage. This antioxidative
property makes CMS-121 an intriguing candidate for addressing diseases
characterized by oxidative stress.
Impact on Aging-related Markers: Preliminary studies conducted on rapidly aging
SAMP8 mice have shown promising results for CMS-121. Oral administration of CMS-121
over a period of 4 months resulted in reduced cognitive decline, improved metabolic
markers, and mitigated transcriptional markers associated with aging in the brain.
Furthermore, CMS-121 was found to preserve mitochondrial homeostasis by regulating
acetyl-CoA metabolism. These findings suggest that CMS-121 may have potential
therapeutic applications in combating age-related cognitive impairments and age-
related molecular changes.

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