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Contact: Ms. Jonna Yuan
Company: YIXING HUADING MACHINERY CO.,LTD.
NO.888#,YIGAO ROAD,YIXING,JIANGSU P.R.CHINA
YIXING 214200
China
Phone: 86-510-87836501
E-Mail: Send Inquiry Member for over 2 years
Date/Time:  1/18/22 7:59 GMT
 

GMP Disc Stack Separator Centrifuge Vaccine Produce

Product Description
Sip system , skid-mounted disc centrifuge separator for vaccine produce



Centrifugal separation technology for vaccine production

Disc separator with SIP&CIP is designed for aseptic processes, which is
becoming increasingly important for handling sensitive products in the
pharmaceutical, biotech and food industries. This is applicable for instance
for the separation of proteins from fermentation solutions for
pharmaceutical products, processing genetically modified micro-organisms or
manufacturing starter cultures in the food and pharmaceutical industries,
production of vaccines or the processing of genetically modified organisms.
Phase separation by means of centrifugal force in a separator is a key
aspect in the process involved. And this important step in the process must
also take place under sterile conditions. This means that the entire
separator system must be steam-sterilizable. All plant components such as
fermenters and receiving tanks for the separated components are connected
aseptically to the system.

Huading Separator has developed the clarifier BTSX-M series in steam-
sterilizable design (SIP) specifically for these fields of application which
has an hourly throughput capacity of 100 to 10,000 liters. The new disk type
separator is suitable for the continuous clarification of suspensions,
separating bacteria, mammalian cells, cell fragments and yeast under sterile
conditions.

Product description

The complete disc separator with SIP&CIP is steam-sterilizable. The machine
is sterilized at rotate using superheated steam at overpressure of 2.5 bar
and a maximum possible temperature of 137 °C. After sterilization, the
separator is blanketed with sterile air, which also cools down the machine,
until the next product run. Sterilization avoids cross-contamination between
different fermentation products which are treated in the same separator.
Chemical cleaning in place (CIP) is carried out before the sterilization
process (SIP). Cleaning liquid is circulated through the separator and the
connected system.

A further aspect in the recovery of proteins in the separator is just as
important as the prevention of product contamination: the guarantee of
biocontainment. Therefore, Huading Separator offers the BTSX-M in steam-
sterilizable design as an absolutely enclosed machine and plant concept
which prevents toxic bacteria or living cell vaccines from escaping into the
atmosphere.

Application:
– insulin
– monoclonal antibodies
– blood-derived products
– vaccine
– sera
– starter cultures
– pharmaceutical proteins
– animal cell cultures
– hormones
other applications, such as E-Coli, inclusion bodies and mammalian cells
starter cultures, such as lactic acid bacteria, fermentation broth and
enzymes treatment of genetically engineered microorganisms.

Main parameter

Voltage 220-440V
Power 4-90KW
HMI SIEMENS
PLC SIEMENS
Frequency converter ABB or CUMARK
Motor ABB or WANNAN


Machine installation

GMP Disc Stack Separator Centrifuge Vaccine Produce 0GMP Disc Stack
Separator Centrifuge Vaccine Produce 1
GMP Disc Stack Separator Centrifuge Vaccine Produce
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