Ketamine, soluble and insoluble form

Ketamine is a dissociative anesthetic widely used in medical practice for
anesthesia, pain management, and, more recently, treatment-resistant
depression. It acts primarily as an NMDA receptor antagonist in the central
nervous system, producing analgesia, sedation, and a trance-like
dissociative state while preserving airway reflexes and cardiovascular
stability. Because of its unique pharmacological profile, it is commonly
used in emergency medicine, surgical anesthesia, and psychiatric settings
under strict medical supervision.

Dosage varies significantly depending on the indication, route of
administration, and patient characteristics. For induction of anesthesia in
adults, intravenous doses typically range from 1 to 2 mg/kg, while
intramuscular doses may range from 4 to 10 mg/kg. For procedural sedation,
lower doses are used, often around 0.5 to 1 mg/kg IV. In the management of
treatment-resistant depression, ketamine is administered at subanesthetic
doses, commonly 0.5 mg/kg infused intravenously over 40 minutes in a
controlled clinical setting. An intranasal formulation (esketamine) is also
approved in some countries and is administered under supervision in
certified healthcare facilities. Dosage must always be individualized and
administered by trained professionals due to variability in patient
response.

Ketamine is a prescription-only medication and is classified as a
controlled substance in many countries due to its potential for misuse and
psychological dependence. It is prescribed by physicians in hospital or
specialized clinic settings, particularly for anesthesia, severe pain, or
psychiatric indications such as major depressive disorder when other
treatments have failed. Strict monitoring is required during
administration, including vital signs, mental status, and cardiovascular
function.

Side effects can occur and range from mild to severe. Common side effects
include dizziness, nausea, vomiting, increased heart rate, elevated blood
pressure, blurred vision, and emergence reactions such as vivid dreams,
hallucinations, or confusion during recovery. These psychological effects
are more common at higher doses or in unsupervised settings. Less common
but serious adverse effects include respiratory depression (rare compared
to other anesthetics), laryngospasm, and prolonged dissociation. With
repeated or chronic use, especially outside medical supervision, ketamine
has been associated with cognitive impairment, urinary tract toxicity
(ketamine-induced cystitis), and potential dependence.

From a clinical perspective, ketamine must be used cautiously in patients
with uncontrolled hypertension, cardiovascular disease, or a history of
psychosis, as it may exacerbate these conditions. Proper screening, dosing,
and monitoring are essential to ensure safety and therapeutic
effectiveness. Overall, ketamine remains a valuable and versatile
medication in modern medicine when used appropriately under professional
supervision.

Minimum Order: 10 grams

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