Natural Gorse Genista Root Extract Genistein Powder 99% CAS 446-72-0

Genistein is a major active factor in soy isoflavones and is the most effective
functional ingredient in soy isoflavones with a variety of physiological
functions. Genistein is structurally similar to mammalian estrogen-estradiol
and has an active group of estrogen-diphenolic hydroxyl group, so genistein has
various physiological activities such as estrogenic activity.

Genistein, which is present in Sophora japonica, is soluble in DMSO and ethanol
and is almost insoluble in water. With estrogen and anti-estrogen properties;
It has anti-oxidant effect; it can inhibit the activity of tyrosine protein
kinase (PTK); it can inhibit the activity of topoisomeric enzyme II; it can
induce programmed cell death, improve the anti-cancer drug effect, and inhibit
angiogenesis.

Genistein is an isoflavonoid phytoestrogenic compound found in soybeans, pea
pods, and other legumes. The estimated human normal dietary intake of
genistein, primarily as glycosides, is 0 to 0.5 mg/kg. Genistein is present in
much greater amounts in nutritional supplements. Genistein is carcinogenic in
female neonatal mice, inducing endocrine-dependent uterine tumors in a fashion
similar to diethylstilbestrol (DES).

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