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For the purpose of medical imaging, a certain substance is introduced into the human body to change the image contrast of local tissues of the body. This introduced substance is Contrast Media, also known as Contrast Agents. As the first Contrast Media manufacturer in China, Beilu Pharma launched the domestic MRI Contrast Media Gadopentetate Dimeglumine Injection in 1992, which broke the foreign products monopoly and filled the domestic gap. As a well-known contrast media manufacturing companies, we could provide a broad portfolio stems Contrast Media across CT/X-ray and MRI modalities, and own the EU standard manufacturing facilities. Types of Contrast Media in Beilu Pharma Magnetic Resonance Imaging (MRI)Contrast Media is Gadolinium based contrast agent(GBCA). It is an intravenous injection, mainly used to enhance the image quality of internal organs, blood vessels and tissues during MRI examinations. GBCA contains gadolinium, which is connected to each other through carrier molecules to form a chelating agent. According to the different chemical structures, this contrast medium can be divided into two categories: linear and macrocyclic. The linear structure of the imaging agents is easier to release gadolinium ions, and the macrocyclic structure of the contrast material is more stable and less likely to release gadolinium ions. CT/X-RAY CONTRAST MEDIA Iodine-containing Contrast Media is one of the common imaging contrast agents used in radiology diagnosis and interventional therapy. It is also a basic diagnosis drug for cardiovascular imaging under X-ray. Currently, the iodinated Contrast Media used for cardiovascular system CT and digital subtraction angiography are all water-soluble organic iodinated contrast materials. Finished Types of Contrast Media S. No Product name Characteristic Specification 1 Gadopentetate Dimeglumine Injection Injectable solution 469mg/ml:  10ml, 12ml, 15ml, 20ml 2 Gadobutrol Injection Injectable solution 604.72mg/ml:  7.5ml 3 Ammonium iron citrate Oral granules 3g：0.6g（Fe 129mg） 6g：1.2g（Fe 258mg） 4 Iopamidol Injection Injectable solution 300mgI/ml:  50ml, 100ml 370mgI/ml:  50ml, 100ml 5 Iodixanol Injection Injectable solution 270mgI/ml:  100ml 320mgI/ml:  50ml, 100ml 6 Iohexol Injection Injectable solution 300mgI/ml:  20ml,50ml,75ml, 100ml 350mgI/ml:  20ml, 50ml, 100ml API & Intermediates Types of Contrast Media S. No Products CAS NO. Packings Classification 1 Iohexol 66108-95-0 25kg Contrast agent 2 Iodixanol 92339-11-2 25kg Contrast agent 3 Iopromide  73334-07-3 25kg Contrast agent 4 Iopamidol 60166-93-0 25kg Contrast agent 5 Ioversol 87771-40-2 25kg Contrast agent 6 Gadopentetate Monomeglumine 92923-57-4 25kg Contrast agent 7 Gadopentetate Dimeglumine 86050-77-3 25kg Contrast agent 8 Gadobutrol 138071-82-6 25kg Contrast agent 9 Calcobutrol 151878-23-8 2kg Excipients 10 Repaglinide 135062-02-1 10kg Anti-diabetic 11 Diethylenetriaminepentaacetic acid ( Pentaacetic Acid)（DTPA） 67-43-6 2.5kg Intermediates 12 Iopamidol Intermediate (order based) 5-Amino-2,4,6-triiodoisophthalic acid 35453-19-1 25kg Intermediates Comparison of physicochemical characteristics of commonly used Contrast Media Contrast media (Concentration：mg（I）/ml) Osmotic pressure (mOsm/kg water） Viscosity （cP，37℃） Iopamidol 300 616 4.7 Ioverol 300 651 5.5 Iohexol 300 672 6.3 Iobitridol 300 695 6 Iodixanol 320 290 11.8 The osmotic pressure of normal people is about 290-300mOsm/kg. Taking the viscosity of water as 1, when the temperature is 37℃, the relative viscosity of whole blood is 4-5, and the relative viscosity of plasma is 1.6- 2.4. Three factors of renal injury induced by Contrast Media: Osmotic pressure, Viscosity and the total iodine. Reduced iodine intake is a feasible strategy to avoid kidney damage. Beilu is a professional contrast media companies, we provide ct contrast agent, mri contrast medium, contrast media products and etc. Want to know more? Please contact us.

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