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Last week, the video I sent to Frank about how hydraulic cartridge valve manufacturer AAK processes the valve spool of hydraulic cartridge flow control valves using a centerless grinder was not approved by him, which made me very disappointed and also helped me understand the requirements of German customers for automated production. Frank from Germany needs to develop a hydraulic flow control valve, but there is a requirement for the accuracy of the valve spool, which requires centerless grinding equipment for precision machining. Frank learned that hydraulic cartridge valve manufacturer AAK has this equipment, so he asked me to take a video of the work for his reference. The next day, Frank said, "Why does it still need a person to assist in completing it?"? I realized that Frank rejected the hydraulic cartridge valve manufacturer AAK because of this. But I'm not too worried, because the automated production process is a strong point of hydraulic cartridge valve manufacturer AAK. Although there is no chance for the hydraulic flow control valve this time, Frank, a customer who is meticulous, will definitely return to AAK. 3 days later, I said to Frank, ‘thank you for your reminder. The mechanical arm plan for automatic material retrieval and feeding equipped for the centerless grinder is already in place. It is expected that in 3 months, I will provide a video of the fully automatic centerless grinder processing the hydraulic flow control valve spool. At the same time, I will also send you some previously unmanned fully automatic processing processes’. Let's go back to last week's video to Frank that using a centerless grinder to process the spool of a hydraulic flow control valve. This CNC centerless grinder is equipped with an automatic conveyor belt. The operator only needs to place the rough machined valve spool on the conveyor belt, and the valve spool is sequentially fed into the grinding area. After one machining is completed, it is automatically placed in the next one. The grinding wheel adopts diamond grinding wheel, which provides a basis for the stable accuracy of the valve spool due to its hardness and wear resistance. The control system of the centerless grinder is stable, with no faults during long-term processing, and the stability of grinding provides assurance for the accuracy and stability of the valve spool. Thanks to Frank's advice again. In fact, the more requirements customers have for you, the more they hope you will grow until you meet the qualifications of their preferred supplier. I like this type of customers. AAK hydraulic cartridge flow control valve, German customer's suggestion, AAK landing, you can also give it a try! AAK HYDRAULIC CARTRIDGE VALVES (745) 2023-12-26 https://www.aakindustry.com/info , -detail/flow-control-valves-aak745

JBFD-H Portable Handheld Type Partial Discharge Tester can be widely used in partial discharge detection of power system, including high voltage switchgear, ring network cabinet, voltage / current transformer, transformer (including dry type transformer), GIS, overhead line, cable and other equipment insulation state detection, through the following indicators to measure the discharge degree of electrical equipment: Partial discharge intensity detection: by measuring the discharge signal in one power frequency cycle, the partial discharge intensity is characterized according to the maximum value (dB) in the discharge pulse sequence. Partial discharge frequency detection: by measuring the discharge signal in one power frequency cycle, the discharge pulse is extracted and the partial discharge frequency is characterized according to the number of discharge pulses. Product Features 1. Configure different sensors to achieve partial discharge detection of almost all high-voltage electrical equipment. 2. Provide time domain waveform, PRPD, PRPS and other discharge patterns to realize the analysis of different discharge types. 3. Humanized man-machine interface facilitates data management of different devices. 4. Built-in ultrasonic sensor and transient ground voltage (hereinafter referred to as TEV) sensor, which can be connected with special sensors such as transformers, GIS, overhead lines, cables, etc. 5. Adopts non-intrusive detection method, no need to power off during the test process, no need to configure additional high voltage source, it is more convenient to use than traditional pulsed partial discharge detector. 6. The test bandwidth range is 30kHz ~ 2.0GHz, which is suitable for detection principles of various frequency bands.

Minimum Order: 1 bags

JBFD-H Handheld Type Partial Discharge Tester is widely used for partial discharge monitoring of power system, including high voltage switchgear, ring network cabinet, voltage/current transformer, transformer (including dry type transformer), GIS, overhead line, cables, and so on. Partial discharge intensity detection: by measuring the discharge signal in one power frequency cycle, the partial discharge intensity is characterized according to the maximum value (dB) in the discharge pulse sequence. Partial discharge frequency detection: by measuring the discharge signal in one power frequency cycle, the discharge pulse is extracted and the partial discharge frequency is characterized according to the number of discharge pulses. Product Features 1. Configure different sensors to achieve partial discharge detection of almost all high-voltage electrical equipment. 2. Provide time domain waveform, PRPD, PRPS and other discharge patterns to realize the analysis of different discharge types. 3. Humanized man-machine interface facilitates data management of different devices. 4. Built-in ultrasonic sensor and transient ground voltage (hereinafter referred to as TEV) sensor, which can be connected with special sensors such as transformers, GIS, overhead lines, cables, etc. 5. Adopts non-intrusive detection method, no need to power off during the test process, no need to configure additional high voltage source, it is more convenient to use than traditional pulsed partial discharge detector. 6. The test bandwidth range is 30kHz -- 2.0GHz, which is suitable for detection principles of various frequency bands.

Minimum Order: 1 bags

IIJ-II-80 Series Transformer Oil Breakdown Voltage Tester is specially designed for testing the breakdown voltage of transformer oil and other kinds of insulating oils. IIJ-II-80 Series Transformer Oil Breakdown Voltage Tester adopts industrial single-chip control system, large-scale integrated circuit, new-style I/O interface, coupled with unique detection and anti-interference technology, the performance of the equipment has been greatly improved. Breakdown voltage testing of insulating oils can help to assess the condition of these oils within electrical equipment, such as transformers, capacitors, switches, etc. Based on the test results, the oil can be identified as aged due to an increase in water content, sludge, or if the oil has oxidized. KEY FEATURES: 1. Simple operation, automatically (can be finished just press one key). 2. Menu controlled. Input data is clear. 3. Can store 99 groups of oil testing data, which is convenient to reading and print. The testing data can keep 10 years under the condition of power off. 4. System time can go on running under power off; (The system time is just for reference which cannot be the standard of timing). 5. High capacity of anti-jamming, high precision of testing. 6. Small volume, light weight, which can be operated in the open air very conveniently. TECHNICAL DATA: 1. Power supply: AC220V ± 10%, 50HZ 2. Output voltage: 80KV, 100KV 3. Capacity: 1.6KVA, 2.0KVA 4. Pressure increase speed: about 2 KVA/S 5. Pressure testing speed: 3% 6. Dielectric strength sensitivity: <2KV 7. Wave form distortion: ≤3% 8. Time of dielectric strength: ≤10MS 9. Electrode gap: 2.5MM 10. Operation environment: Temperature: 0℃ - 40℃, Humidity: ≤ 85%RH 11. Storage environment : Temperature: -20℃ - 40℃, Humidity: ≤ 75%RH 12. Working altitude: <1500m (if over 1500m can be designed specially) 13. Packing: Wooden Case

Minimum Order: 1 bags

Zing Ear G3 series switch is a kind of subminiature waterproof micro switch and with IP67 function. So most the designer will use them to resist a wet environment, such as tap, automotive accessories, electric toothbrush, Electric-drive airer, Shared umbrella, waterproof power bank, vacuum cleaner, and so on. In summary, the G3 Subminiature Sealed Micro Switch is widely used in automobile parts and household appliances. Meanwhile, in order to meet different installing requirements, there have various items for options. For example, you need a switch can install M3 screw, we will provide the item to you. And if you need PCB terminals type, it is also available too so any item you need, any item we can provide.

Minimum Order: 100

The G606 micro switch series has double pole double throw, double pole single throw NO, and double pole single throw NC circuitry for your options. Buyers can choose the circuit as they want. Its rating is “0.5A 125/250 VDC” and “6A 125/250VAC, 1/4HP 250VAC”, so it can be used in the DC or AC voltage environment. Which has gained the safety certification of UL & cUL. Meanwhile, it is widely used in industrial control, home automation, and so on. Such as the float, sewage pump, condensate pump, linear actuator, etc. website:https://www.grandye-switch.com , /g606-double-pole-switches

Minimum Order: 100

As microswitch, G10 is a subminiature micro switch. Speaking about this item, the most different with other switch is the size. The length of it is 12.8mm only actually. I mean that it can be used in mouse, electric knife and stapler, calculator, and so on. What’s more, we can do the parameters and part as buyer requirement. Such as operating force, rating, terminal and lever types, etc. Meanwhile, these subminiature micro switches have a wide appplication in office equipment and household appliances. Such as the mouse, electric knife, electric stapler, telephone, calculator, alarm, cleaner, and so on. Besides, in order to ensure the switch quality, our products also have UL, cUL, ENEC, and CQC certifications.

Minimum Order: 100

The G6 Miniature Micro Switch series is small in size and high quality, widely used in household appliances and auto parts such as Timmer, Pump, Computer, Air conditioners, humidifiers, pushrods, Tubular moto, and so on. Because the G6 series are wide applications on the market, they have many different kinds of parameters for customer choice. For example, there are 0.1A, 5A, 10A, and 12A for the current options. Besides, silver contact and gold contacts are also available too. As well as the terminals, levers, operating force, and circuit code. This product not only has global safety approvals to make sure quality but can provide a customized design for buyer requirements as well.

Minimum Order: 100

Widely Targeted Metabolite Detection MWDB Major Upgrade: 20,000 plant metabolites MWDB (Metware Database) can now detect 20000 types of plant metabolites Since 2014, Metware Biotechnology has been pushing the boundaries of metabolite detection. Our featured product Widely-Targeted Microbiome Metabolomics for Plants has been undergoing a major upgrade this year where our identifiable plant endogenous metabolites rose to 20,000, a doubling from our previous plant metabolomics database of 10,000! Average identified metabolites: 1,300 metabolites detected in real samples Applying this database to the detection of different species or tissue types, the average number of substances detected in a sample can be as much as 1300. Below, we present real outputs using Oryza sativa samples. Unvealing the data: The graph below shows different tissues types from O. sativa averages to 1300 identified metabolites. The data reveals that we can detect over 800 secondary metabolites and over 400 primary metabolites. Our observations here is in concordance with published literature where primary metabolites in plants are relatively conserved ranging around 1000 types, whereas secondary metabolites vary greatly between species and can range from 0.2 ~ 1 million. This is a significant improvement in identifying secondary metabolites in plants. Analysis of detected metabolites: wide-coverage Analyzing the metabolites in various tissues, we find that flavonoids and phenolic acids stands out whereas other metabolites show large differences between tissue types. Due to these differences, it is best to cover all types of metabolites in a metabolomics study. Reference: 1. A multi-omic study uncovers a bZIP23-PER1A–mediated detoxification pathway to enhance seed vigor in rice. 2. Rice metabolic regulatory network spanning its entire life cycle. 3. A molecular switch in sulfur metabolism to reduce arsenic and enrich selenium in rice grain. 4. Loss function of SL (Sekiguchi lesion) in the rice cultivar Minghui 86 leads to enhanced resistance to (hemi)biotrophic pathogens. 5. Transcriptomic and Metabolomic Responses of Rice Plants to Cnaphalocrocis medinalis Caterpillar Infestation. 6. Dynamic transcriptome and metabolome project analyses of two types of rice during the seed germination and young seedling growth stages. 7. Analysis of Global Methylome and Gene Expression during Carbon Reserve Mobilization in Stems under Soil Drying. 8.UDP-glucosyltransferase regulates grain size and abiotic stress tolerance associated with metabolic flux redirection in rice.

What Is Untargeted Metabolomics? HomeMetabolomics ServicesGlobal Metabolite ProfilingUntargeted Metabolomics untargeted metabolomics service The LC-MS untargeted metabolomics is used for unbiased detection of metabolites in samples by liquid chromatography-mass spectrometry and to obtain their qualitative and quantitative information. Untargeted metabolomics data analysis, also known as nontargeted metabolomics analysis, entails comparing the metabolomes of control and test groups to pinpoint distinctions in their metabolite profiles that could be pertinent to specific biological conditions. Technology Introduction The main application of lcms metabolomics is for comparing the case group with the control group to find the metabolites and metabolic pathways that show significant differences between groups, which can provide clues and directions for the untargeted metabolomics research in biomarker development, disease pathogenesis, and drug treatment mechanisms. Technical Features of Untargeted Metabolomics Service  Large Curated Database Collected ultra-high sensitinity data of over 280,000 metabolites. Each sample can typically identify 1500-3000 metabolites. Comprehensive Identification Strategy A comprehensive identification of metabolites was performed using four qualitative methods: Matching to in-house standard database; Matching to integrated public database; Matching to AI database; Identify using the metDNA algorithm. Rigorous Quality Control A mature quality control system monitoring all aspects of experimentation from sample preparetion to data collection. Why Untargeted Metabolomics Service Is Used? Genes will tell you what may happen, metabolites tell you what is happening or has happened (Bill Lasley) Metabolomics is the qualitative and quantitative assessment of metabolites (small chemical molecules<1.5 kda). The metabolites are the downstream product of protein activity as well as the result of interactions with environmental exposures, and thus they are closely related to the phenotype. Over the last decade, metabolomics is coming to the forefront as a powerful tool for understanding disease mechanisms. and identifying biomarkers, and has great potential for clinical translation. As a preeminent metabolomics company with a well-equipped metabolomics laboratory, we provide cutting-edge metabolomics services through scientific metabolomics test and analysis. As a preeminent metabolomics company with a well-equipped metabolomics laboratory, metware library provides cutting-edge metabolomics services through scientific metabolomics test and analysis.

HomeMetabolomics ServicesMulti-OmicsTranscriptome+Metabolome tra , nscriptome metabolome services The transcriptome is an important method to obtain gene expression in a biological system, and the metabolome is the basis and direct readout of the system’s phenotype. The metabolites are the final result of gene transcription under internal and external regulation and are the material basis of the observed phenotype. In the era of systems biology research, biological processes and gene regulatory networks are complex and dynamic. It is often insufficient to use a single dataset to study systems biology. Correlating transcriptomic data that has a large number of differentially expressed genes with differential metabolites detected by metabolomics can pinpoint key genes, metabolites, and metabolic pathways that are closely associated with internal changes in the system, and thereby explain biological problems in a more holistic approach. Technology Introduction of Transcriptomics and Metabolomics Services Correlating transcriptomic data that has a large number of differentially expressed genes with differential metabolites detected by metabolomics and multi-omics can pinpoint key genes, metabolites, and metabolic pathways that are closely associated with internal changes in the system, and thereby explain biological problems in a more holistic approach. Case Study: The Cardamine Enshiensis Genome Reveals Whole Genome Duplication And Insight Into Selenium Hyperaccumulation And Tolerance (Huang Et Al., Cell Discovery 2021) To better understand the mechanisms of Se tolerance in Cardamine enshiensis, the authors constructed the 443Mb genome for C. enshiensis and performed RNA- seq and Widely-Targeted Metabolomics on seedlings treated with water (control) or 400uM sodium selenite. Mechanisms of Se tolerance and hyperaccumulation in C. enshiensis In total, 29,671 differentially expressed genes were identified and a total of 558 metabolites were identified in the leaf tissue of C. enshiensis, of which 127 were differential metabolites. The authors found 10 flavone-related metabolites were altered between the two groups, indicating that flavones play a pivotal role in Se tolerance. KEGG analyses showed the significantly enriched pathways were associated with the biosynthesis of secondary metabolites and flavone/flavonoid/flavonol compounds. A Pearson’s correlation coefficient threshold of r > 0.8 was used to identify the metabolites that were significantly correlated with each gene and the results revealed that 175 transcripts were highly correlated (R2 > 0.96) with tricetin O-malonylhexoside and amentoflavone. If you want to know more about RNA-seq and metabolomics, please visit our website. As a preeminent metabolomics company with a well-equipped metabolomics laboratory, we provide cutting-edge metabolomics services through scientific metabolomics test and analysis. As a preeminent metabolomics company with a well-equipped metabolomics analysis laboratory, we provide cutting-edge metabolomics services through scientific metabolomics test and analysis. More details of metabolome project, please visit our website.

HomeMetabolomics ServicesGlobal Metabolite ProfilingTM Widely-Targeted Metabolomics tm widely targeted metabolomics service 1 TM Widely-targeted metabolomics is the 'Untargeted metabolomics + Targeted Metabolomics' process that achieves the perfect combination of high resolution, wide-coverage, high sensitivity, and precise quantification. It is a great starting point to examine the global metabolite profile. Metware's curated database of 280,000 metabolites, which includes 3000 metabolites not found in public databases, allows more annotations from high-resolution mass spec data. Technology Introduction "TM" Widely-Targeted Metabolomics combines Untargeted metabolomics and Targeted metabolomics to achieve the perfect combination of high-resolution, wide- coverage, high-sensitivity, and precise quantification. Metware library's patented Widely-Targeted Metabolomics technology stands out from many others with features such as: Using high-resolution mass spectrometers to allow the unbiased collection of MS/MS spectrum data; High resolution metabolomics database with over 3000+ in-house metabolite database providing more metabolite annotation; Using MRM analysis from QQQ to accurately quantify metabolites in each sample. Technology Introduction TM Widely-Targeted Metabolomics Analysis Service Technical Features  Large Curated Database Collected ultra-high resolution data of over 280,000 metabolites. Each sample can typically identify over 1400 metabolites. Rigorous Quality Control A mature quality control system monitoring all aspects of experimentation from sample preparetion to data analysis. Experienced Stable and tested sample preparation protocol stemming from processing over a million samples a year. Accurate Identification Combining AB SCIEX QTOF 6600+ ultra-high resolution mass spectrum with our large curated database to achieve accurate metabolite identification. Accurate Quantification Using MRM mode from AB SCIEX Triple Quad 6500+ to achieve accurate relative quantification of metabolites. If you want to know about targeted metabolomics workflow and metabolite discovery through global annotation of untargeted metabolom, please visit our website.

T500 is a targeted-metabolomics method that are both extensive and accurate in identification and quantification of 540 disease-related metabolites. Each metabolite is matched and quantified to chemical standards to obtain absolute quantification. Technology Introduction T500 is our most comprehensive targeted-metabolomics service that is both extensive and accurate in the identification and quantification of 540 well- known metabolites. These metabolites were chosen by our metabolite panel for their close association with various neurological diseases, metabolic diseases, gastrointestinal diseases, lung diseases, reproductive diseases, liver diseases, and cancer. Technology Introduction Technical Features of T500 Targeted Metabolomics Analysis Service  Only Need One Only one sample needed, saves time and avoids collecting large number of replicates. Wide Coverage 540 metabolites in 9 metabolic pathways. Absolute Quantification using 540 standard curves with r > 0.99. From targeted assays of specific metabolites to global metabolite profiling, Metware library has developed services that can satisfy every project, all the while keeping the most important in mind: data quality. Not sure which services work for you? Contact us to speak with one of our specialists and let us help you design a metabolomics project suitable for your research and development.

Home Metabolomics Services Multi-Omics Resequencing and Metabolomics resequencing metabolome services The types and quantities of metabolites vary greatly in different species and tissues. The mGWAS (metabolome Genome-Wide Association Study) approach uses population materials, based on resequencing genetic information and metabolomics data to carry out genome-wide association analysis between genomic variations and metabolite quantities. Case Study: Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism (Chen et al., Nature Genetics 2014) Subspecies specific metabolites between two rice subspecies Using 529 rice leaf materials, a total of 840 compounds were detected by Widely-Targeted Metabolomics. Cluster analysis of these metabolites identified C-glycosylated and malonylated flavonoids accumulated more in the O. indica, while the O. japonica contained large amounts of phenolamides and arabidopyl alcohol derivative compounds. These subspecies-specific metabolites reflect the differentiation of O. indica and O. japonica. SNP analysis and metabolite association of the rice population Using NGS on the 529 materials, 6,428,770 SNPs were screened for further analysis. Simple linear regression (LR) and linear mixed models (LMM) were used for mGWAS analysis and a total of 2,947 major SNPs were identified, corresponding to 634 loci in at least one population. 161 significant loci shown on the Manhattan plot correspond to flavonoids, phenolic compounds, amino acids and their derivatives, terpenoids, nucleic acids and their derivatives, and other known metabolites. In addition, there are 195 loci corresponding to unknown metabolites. Case Study mGWAS assists with annotation of unknown metabolites mGWAS facilitates the annotation of metabolites by associating unknown metabolites with functionally relevant genes. For example, SNP sf1207801034 in the NOMT gene encoding naringenin 7-O-methyltransferase correlated with mr1002 levels, suggesting that this metabolite may be sakuranetin. Subsequently, the mr1002 metabolite was proven to be sakuranetin by comparing the retention time and fragmentation pattern with the chemical standard of this compound. In this study, GWAS was able to annotate 166 unknown metabolites. Case Study Biochemical and functional interpretation of GWAS results In addition to providing insight into the genetic basis of metabolic changes, mGWAS also provide insight into the biochemistry and function of underlying pathways. We can examine previously unidentified candidate genes by (i) finding genes or gene clusters associated with the relevant metabolic signatures encoded by these loci; (ii) clustering candidate genes with homologous genes with known functions; (iii) cross-reference genetic map results. We hope to uncover candidate genes or SNPs valuable for plant physiological or human nutrition. For instance, trigonelline, an N-methyl conjugate of nicotinic acid, has long been reported to regulate various processes, especially abiotic stress in plants, but the enzyme that catalyzes niacin to trigonelline was unknown at the time. Trigonelline levels were significantly correlated with SNP sf0235317720 on chromosome 2, which was in linkage disequilibrium with the Os02g57760 gene encoding an O-methyltransferase protein, indicating that Os02g57760 encodes a key methyltransferase that catalyzes trigonelline biosynthesis. When N-terminal His-tagged Os02g57760 was expressed in E. coli BL-21, we were able to detect niacin:N-methyltransferase activity in soluble protein extracts. Consistent with the in vitro activity, overexpression of Os02g57760 in ZH11 (an O. japonica cultivar with low trigonelline content) resulted in a greater accumulation of trigonelline in the transgenic lines compared to control plants, confirming that Os02g57760 catalyzes trigonelline biosynthesis. From targeted assays of specific metabolites to global metabolite profiling, Metware Biotechnology has developed services that can satisfy every project, all the while keeping the most important in mind: data quality. Not sure which services work for you? Contact us to speak with one of our specialists and let us help you design a metabolome project suitable for your research and development.